English
BIOGRAPHICAL SKETCH:
Dr. sc. hum. Deni Hardiansyah
Medical Physics and Biophysics Research Group,
Physics Department, Faculty of Mathematics and Natural Sciences (FMIPA),
Universitas Indonesia, Indonesia.
Building F (Physics Department), FMIPA UI, University of Indonesia, Depok, 16424
Email:
(University): denihardiansyah@ui.ac.id
(Faculty): denihardiansyah@sci.ui.ac.id
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Qualifications
Education
Dr. Hardiansyah is a lecturer at the Physics Department FMIPA, Universitas Indonesia. Dr. Hardiansyah earned a doctoral degree at Heidelberg University, Germany, with a focus on the implementation of physiologically based pharmacokinetic (PBPK) model to improve individual dosimetry in Molecular Radiotherapy. In addition to the Molecular radiotherapy, he also published several papers in the field of molecular/functional imaging. After his PhD, he worked as a postdoc and staff at the College of Pharmacy, University of Kentucky, USA, in the field of pharmaceutical sciences. In general, he has carried out research in various aspects of nuclear medicine dosimetry, imaging and modeling of drug’s PKPD.
2013 – 2016 Dr. sc. hum. (2.5 years), Heidelberg University, Germany
2011 – 2013 MSi. (1.5 years), Institut Teknologi Bandung, Indonesia
2006 – 2010 SPd. (3 years and 10 months), Universitas Pendidikan Indonesia, Indonesia
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About
Dr. Hardiansyah is a lecturer at the Physics Department FMIPA, Universitas Indonesia. Dr. Hardiansyah earned a doctoral degree at Heidelberg University, Germany, with a focus on the implementation of physiologically based pharmacokinetic (PBPK) model to improve individual dosimetry in Molecular Radiotherapy. In addition to the Molecular radiotherapy, he also published several papers in the field of molecular/functional imaging. After his PhD, he worked as a postdoc and staff at the College of Pharmacy, University of Kentucky, USA, in the field of pharmaceutical sciences. In general, he has carried out research in various aspects of nuclear medicine dosimetry, imaging and modeling of drug’s PKPD.
2013 – 2016 Dr. sc. hum. (2.5 years), Heidelberg University, Germany
2011 – 2013 MSi. (1.5 years), Institut Teknologi Bandung, Indonesia
2006 – 2010 SPd. (3 years and 10 months), Universitas Pendidikan Indonesia, Indonesia
2013-2016 BPPLN Scholarships for Doctoral Degree from DIKTI
2011-2013 BPPDN Scholarships for Master Degree from DIKTI
2006-2010 PSF Scholarships for Bachelor Degree from Putera Sampoerna Foundation
2022 World Class Professor Grant from DIKTI
2021 Science & Technology Research Grant 2022 from Indonesian Toray Science Foundation (ITSF) for Molecular Radiotherapy Research Project.
2021 International Best Abstract at the SNMMI Virtual Conference 2021, USA
2020 Top Rated Oral Presentation at EANM Conference 2020
2018-2019 Top Downloaded Paper 2018-2019 Award in Clinical and Translational Science Journal
2017 International Best Abstract at the SNMMI Conference 2017, Denver, USA
2016 Travel Award recipient from Heidelberg University to attend SNMMI Conference 2016, San Diego, USA
2019-now Lecturer at Physics Department, FMIPA, Universitas Indonesia, Indonesia
2016-2019 Postdoctoral scholars and Staff at University of Kentucky, USA
Research Interest
Book Chapter
Medical Physics
Nuclear Medicine
Molecular Radiotherapy
Peptide-Receptor Radionuclide Therapy (PRRT)
Peptide Specific Membrane Antigen (PSMA) Therapy
Molecular/Functional Imaging
Pharmaceutical Sciences
Physiologically-Based Pharmacokinetic (PBPK) Modeling
Quantitative Systems Pharmacology (QSP) Modeling
Hardiansyah D, Ng CM. Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases. Chapter: Quantitative Pharmacology Approach to Select Optimal Dose and Study the Important Factors in Determining Disposition of Therapeutic Monoclonal Antibody in Pediatric Subjects – Some Considerations. March 2019. Wiley, ISBN: 978-1-119-28919-7.
Publications
- Hardiansyah D, Riana A, Beer A, Glatting G. Single-time-point estimation of absorbed doses in PRRT using a non-linear mixed-effects model. Z Med Phys. 2022;in print 12 July 2022.
- Hardiansyah D, Ng CM. Minimal Physiologically-based Pharmacokinetic Model to Investigate the Effect of Charge on the Pharmacokinetics of Humanized anti-HCV-E2 IgG Antibodies in Sprague-Dawley Rats. Pharm Res. 2022;39:481-96.
- Hardiansyah D, Riana A, Kletting P, Zaid NRR, Eiber M, Pawiro SA, Beer AJ, Glatting G. A population-based method to determine the time-integrated activity in molecular radiotherapy. EJNMMI Phys. 2021 Dec 14;8(1):82. doi: 10.1186/s40658-021-00427-x. PMID: 34905131.
- Hardiansyah D, Kletting P, Begum NJ, Eiber M, Beer AM, Pawiro SA, and Glatting G. Important pharmacokinetic parameters for individualization of (177) Lu-PSMA therapy: A global sensitivity analysis for a physiologically-based pharmacokinetic model. Med Phys. 48:556-568 (2021).
- Hardiansyah D*$, Attarwala AA*, Romano C, Jimenez-Franco LD, Roscher M, Wangler B, and Glatting G. Performance assessment of the ALBIRA II pre-clinical SPECT S102 system for (99m)Tc imaging. Annals of nuclear medicine. 35:111-120 (2021). *equal contribution.$corresponding author
- Hardiansyah D, Ng CM. Quantitative Systems Pharmacology Model of Chimeric Antigen Receptor T cell Clin Transl Sci. 2019;12(4):343-349.
- Hardiansyah D, Ng CM. Minimal Physiologically-based Pharmacokinetic Model to investigate the Effect of pH Dependent FcRn Affinity and the Endothelial Endocytosis on the Pharmacokinetics of Anti-VEGF Humanized IgG1 Antibody in Cynomolgus Monkey. Eur J Pharm Sci. 2018;125:130-141.
- Hardiansyah D, Ng CM. Effects of the FcRn developmental pharmacology on the pharmacokinetics of therapeutic monoclonal IgG antibody in pediatric subjects using minimal physiologically-based pharmacokinetic modelling. mAbs. 2018;10(7):1144-1156.
- Hardiansyah D, Ng CM. Two-Pore Minimum Physiologically-based Pharmacokinetic Model to Describe the Disposition of Therapeutic Monoclonal IgG Antibody in Humans. Pharmaceutical Research. 2018.35(3):47.
- Hardiansyah D, Maass C, Attarwala AA, Müller B, Kletting P, Mottaghy FM, Glatting G. The Role of Patient-Based Treatment Planning in Peptide Receptor Radionuclide Therapy. Eur J Nucl Med Mol Imaging. May 2016;43(5):871-880.
- Hardiansyah D*, Attarwala AA*, Romano C, Roscher M, Molina-Duran F, Wangler B. Glatting G. A method for point spread function estimation for accurate quantitative imaging. IEEE Transactions on Nuclear Sciences. 2018. 65(3):961-969 *equal contribution.
- Hardiansyah D*, Attarwala AA*, Kletting P, Mottaghy FM, Glatting G. Prediction of time- integrated activity coefficients in PRRT using simulated dynamic PET and a pharmacokinetic model. Physica Medica. 2017;42:298-304. *equal contribution.
- Hardiansyah D, Begum NJ, Kletting P, Mottaghy FM, Glatting G. Sensitivity Analysis of a PBPK Model Used for Treatment Planning in Molecular Radiotherapy. Cancer Biother Radiopharm. Aug 2016;31(6):217-224.
- Hardiansyah D, Guo W, Kletting P, Mottaghy FM, Glatting G. Time-integrated activity coefficients estimation for radionuclide therapy using PET and a pharmacokinetic model: A simulation study on the effect of sampling schedule and noise. Med Phys, 2016. 43(9): p. 5145.
- Hardiansyah D, Guo W, Attarwala AA, Kletting P, Mottaghy FM, Glatting Treatment planning in PRRT based on simulated PET data and a PBPK model. Determination of accuracy using a PET noise model. Nuklearmedizin. 2017. 56(1):23-30.
- Maaß C, Rivas JRA, Attarwala AA, Hardiansyah D, Niedermoser S, Litau S, Wängler C, Wängler B, Glatting G. Physiologically based pharmacokinetic modeling of 18F-SiFAlin– Asp3-PEG1-TATE in AR42J tumor bearing mice. Nucl Med Biol. Apr 2016;43 (4):243-246.
- Maaß C, Sachs JP, Hardiansyah D, Mottaghy FM, Kletting P, Glatting G. Dependence of treatment planning accuracy in peptide receptor radionuclide therapy on the sampling schedule. EJNMMI Res. Dec 2016; 6(1):30.
- Attarwala AA, Karanja YW, Hardiansyah D, Romano C, Roscher M, Wängler B, Glatting G. Investigation of the Imaging Characteristic of the ALBIRA II Small Animal PET Imaging System for 18F, 68Ga and 64 Zeitschrift für Medizinische Physik. 2017. 27(2):132-144.
- AD Widyanugraha, N Atikah, D Hardiansyah. Estimation of The Main Effect and Total Effect of a PBPK Model Based on The Uncertainty of Individual Parameter for Treatment Planning in PSMA Therapy. IOP Conference Series: Earth and Environmental Science 913 (1), 012101
- N Atikah, A Riana, A Dwi, Z Anwari, D Hardiansyah. Model Selection in Peptide-receptor Radionuclide Therapy for an Accurate Determination of Time Integrated Activity Coefficients. Journal of Physics: Conference Series 2019 (1), 012079
- A Jadidan, MZ Anwari, A Riana, YW Sari, D Hardiansyah. Biodistribution study of lutetium hydroxyapatite (177Lu-HA) for liver cancer therapy. ICSPMB Conference 2020. AIP Conference Proceedings2346 (1), 030001
- M Hasril, M Luthfy, A Riana, AN Ittaqa, SA Pawiro, D Hardiansyah. Study the effect of the physiological parameters to the optimal administration of lysine/arginine during peptide receptor radionuclide therapy (PPRT) using a physiologically-based pharmacokinetic (PBPK) model. ICSPMB Conference 2020. AIP Conference Proceedings2346 (1), 030004.
- MZ Anwari, TS Humani, NR Hidayati, D Hardiansyah. Effect of different radiopharmaceutical drug to the performance of translation methods of TIACs from mice to human. ICSPMB Conference 2020. AIP Conference Proceedings2346 (1), 030005
- LD HAM, Misrawati, AN Ittaqa, A Riana, D Hardiansyah. Study of the most important physiologic parameter using GSA with sobol method and a PBPK model for individualization of peptide-receptor radionuclide therapy. SNF Conference 2020. AIP Conference Proceedings2320 (1), 050030.
- A Riana, SA Pawiro, D Hardiansyah. Study of population and covariate model in physiologically based pharmacokinetics model used for treatment planning in peptide receptor radionuclide therapy. SNF Conference 2020. AIP Conference Proceedings2320 (1), 050015.
- AN Ittaqa, SA Pawiro, A Riana, LDHA Mas’udi, D Hardiansyah. Estimation of main and total effect of PBPK parameters in Meningioma patients. ICTAP 2020. Journal of Physics: Conference Series1816 (1), 012101.
- Hidayati NR, Hardiansyah D, Glatting G. Effect of Deviation in Image Quantification for Internal Dosimetry Assessment in Radionuclide Therapy. Research and Development on Nanotechnology in Indonesia. ISSN: 2356-3303. p. 49-51. V2. 2015.
- Hardiansyah D, Male S, Haryanto F. Study the Sensitivity of Dose Calculation in PRISM Treatment Planning System Using Monte Carlo Simulation of 6 MeV Electron Beam. SEACOMP 2014. AIP Conf. Proc. 1615, 213 (2014).
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Students
- Azka Bela Fadliyanti
- Zaidi Anwari
- Indah R. Apriani
- Nining Pratiwi
- Fauzan
- Adelia
- Annisa
- Aviana (2022)
Supervisors: Dr. sc. hum. Deni Hardiansyah and Intan AS Mu’minah, MSi. (UI)
Bachelor thesis: In-house software for the calculation of TIACs uncertainty.
- Akhmad J. (2022)
Supervisors: Dr. sc. hum. Deni Hardiansyah
Bachelor thesis: Effect of starting point to the calculation of TIAC using a PBPK Model.
- Defia A. (2022)
Supervisors: Dr. sc. hum. Deni Hardiansyah
Bachelor thesis: Development of a PBPK model for Nivolumab in Mice.
- Deyan Prasha (2022)
Supervisors: Dr. sc. hum. Deni Hardiansyah and Intan AS Mu’minah, MSi. (UI)
Bachelor thesis: In-house software for dosimetry of 177Lu.
- Dlorifun Naqiyyun (2022)
Supervisors: Dr. sc. hum. Deni Hardiansyah
Master thesis: Calculation of TIACs using a single-time point data and Bayesian Fitting method.
- Farah Fauziah Arditami (2021)
Supervisors: Dr. sc. hum. Deni Hardiansyah
Bachelor thesis: Calculation of TIACs using in-house software and PBPK model.
- Lazuardi Akbar (2021)
Supervisors: Dr. sc. hum. Deni Hardiansyah and Intan AS Mu’minah, MSi. (UI)
Bachelor thesis: In-house software for dosimetry in thyroid cancer based on safety.
- Rahmatul Hanifah (2021)
Supervisors: Dr. sc. hum. Deni Hardiansyah
Master thesis: Investigate the effect of model selection to the accuracy of one-time point dosimetry method by Hanceid etal.
- Agesta Dwi Widyanugraha (2021)
Supervisors: Dr. sc. hum. Deni Hardiansyah
- Ai Nurainun Ittaqa. (2021)
Supervisors: Dr. Suprianto A. Pawiro and Dr. sc. hum. Deni Hardiansyah
Master thesis: Estimation of the Main effect and Total effect in Meningioma Patient
- Nur Atikah. (2021)
Supervisor: Dr. sc. hum. Deni Hardiansyah
Master Thesis: Study the reproducibility of model selection output in PRRT
- Ja’far Hilmi Farhan. (2021)
Supervisor: Dr. sc. hum. Deni Hardiansyah
Bachelor Thesis: Study the effect of uncertainty on the clustering output based on k-means
- Yuan Hasanah Maharani. (2021)
Supervisors: Dr. sc. hum. Deni Hardiansyah and Intan AS Mu’minah, MSi. (UI)
Bachelor Thesis: Software Development for Planar Images Quantification Based on Conjugate View Counting Method.
- Andini Ayu Pramesti. (2021)
Supervisors: Dr. sc. hum. Deni Hardiansyah and Intan AS Mu’minah, MSi. (UI)
Bachelor Thesis: Software Development for Estimation of Spatial Resolution Based on 4D Gaussian Method.
- Syafira Nurin Aqmarina. (2021)
Supervisors: Dr. sc. hum. Deni Hardiansyah and Intan AS Mu’minah, MSi. (UI)
Bachelor Thesis: Software Development for Treatment Planning of Thyroid Cancer Based on Efficacy.
- Atika Prevanti Nabila. (2021)
Supervisors: Dr. sc. hum. Deni Hardiansyah and Prof. Djarwani S. Soejoko.
Bachelor Thesis: Accuracy of Small Lesion Detection using K-Means Clustering and special Cylindrical Phantom.
- Yuli Herawati. (2021)
Supervisors: Dr. sc. hum. Deni Hardiansyah and Intan AS Mu’minah, MSi. (UI)
Bachelor Thesis: Development of In-House Software for Spatial Resolution Analysis using 2D and 3D method.
- Misrawati. (2020)
Supervisors: Dr. Supriyanto A. Pawiro and Dr. sc. hum. Deni Hardiansyah.
Master Thesis: Biodistribution study of Lysine and Arginine for PRRT using Physiologically-Based Pharmacokinetic (PBPK) Model.
- Abyan Jadidan. (2020)
Supervisors: Dr. sc. hum. Deni Hardiansyah and Dr. Yessie Widya Sari (IPB University).
Bachelor Thesis: Biodistribution Study of 177Lu-HA for Therapy of Heart Cancer.
- Luthfy Dzikrillah (2020)
Supervisor: Dr. sc. hum. Deni Hardiansyah.
Bachelor Thesis: Study the Most Important Physiologic Parameter using GSA with Sobol Method and a PBPK model for Individualization of PRRT.
- Aldiman Bakhti. (2020)
Supervisors: Dr. sc. hum. Deni Hardiansyah and Intan AS Mu’minah, MSi. (UI)
Bachelor Thesis: Development of In-House Software for Evaluation and Identification of Ring Artifacts in SPECT images.
- Ade Riana (2020)
Supervisors: Dr. Supriyanto A. Pawiro and Dr. sc. hum. Deni Hardiansyah.
Master Thesis: Study of Population and Covariate Model in Physiologically-based Pharmacokinetics Model used for Treatment Planning in Peptide Receptor Radionuclide Therapy.
- M. Zaidi Anwari (2019)
Supervisors: Dr. sc. hum. Deni Hardiansyah and Nur Rahmah Hidayati, MSi.(BATAN).
Bachelor Thesis: Translation of the Biodistribution of 177Lu-DOTA-TRASTUZUMAB from Mice to Human.
- Ade Riana. (2022)
Achievement: Best Presenter for Nuclear Medicine at PITFMB Conference.
- Dlorifun N. (2022)
Achievement: Travel award from SEAFOMP to attend IUPESM Conference.
- Ade Riana. (2021)
Achievement: International Best Abstract at the SNMMI Virtual Conference 2021, USA
- Yuli Herawati. (2021)
Achievement: Best presentation at 6th International Science of Mathematics Academics Research Talks (ISMART) 2021.
- Abyan Jadidan. (2020)
Achievement: Best Presenter award for Nuclear Medicine Topic at ICSPMB conference 2020.